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xutianying@smmu.edu.cn
wzm11998@163.comElevated bile acid concentrations impair myocardial structure and function by disrupting mitochondrial integrity and acting on TGR5 and FXR receptors.
Endotoxins contribute to cardiovascular dysfunction by exacerbating systemic inflammation, primarily via NF-κB activation and increased levels of pro-inflammatory cytokines such as TNF-α.
Reactive oxygen species alter cardiac electrophysiology by modulating L-type calcium channels and reversing Na+/Ca2+ exchanger activity, leading to contractile dysfunction. Excessive nitric oxide disrupts vascular tone regulation.
Autophagy is activated through the AMPK-mTOR-ULK1 signaling pathway, while apoptosis-driven myocardial injury is mediated by caspase activation and the Bax/Bcl-2 protein family.
Appropriate preoperative management, anesthetic selection, and the application of traditional Chinese medicine can alleviate cardiac injury associated with obstructive jaundice.
Open Accessxutianying@smmu.edu.cnwzm11998@163.comElevated bile acid concentrations impair myocardial structure and function by disrupting mitochondrial integrity and acting on TGR5 and FXR receptors.
Endotoxins contribute to cardiovascular dysfunction by exacerbating systemic inflammation, primarily via NF-κB activation and increased levels of pro-inflammatory cytokines such as TNF-α.
Reactive oxygen species alter cardiac electrophysiology by modulating L-type calcium channels and reversing Na+/Ca2+ exchanger activity, leading to contractile dysfunction. Excessive nitric oxide disrupts vascular tone regulation.
Autophagy is activated through the AMPK-mTOR-ULK1 signaling pathway, while apoptosis-driven myocardial injury is mediated by caspase activation and the Bax/Bcl-2 protein family.
Appropriate preoperative management, anesthetic selection, and the application of traditional Chinese medicine can alleviate cardiac injury associated with obstructive jaundice.
Obstructive jaundice can lead to systemic multi-organ complications, with the heart being one of the most critically affected organs. This review summarizes recent insights into the mechanisms of cardiac injury induced by obstructive jaundice, including bile acid toxicity, inflammatory responses, oxidative stress, nitric oxide dysregulation, endotoxemia, apoptosis, and autophagy. Currently, no specific treatment protocol exists for this condition. However, appropriate anesthetic choices, traditional Chinese herbal medicine, and optimized perioperative management have shown potential in mitigating myocardial damage. This review provides a detailed discussion of these aspects.
ISSN: 2957-5443
Volume 3, Issue 1
March 2025
Pages: 1-38
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