Review Article

Open Access

2025 Jun;3(2):54-70

https://doi.org/10.61189/629158xrbqam

Impact of intestinal immunologic barrier dysfunction on perioperative complications

Wenxin Shi

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Yajun Hu

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Jin Lan

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Jun Xiong

xiongjun2001@163.com

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Zhiyong Li

zhiyongli@smmu.edu.cn

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

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Article notes

Highlights

Jun Xiong, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: xiongjun2001@163.com; Zhiyong Li, Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Xiangyin Road, Yangpu District, Shanghai 200082, China. E-mail: zhiyongli@smmu.edu.cn.

Received October 28, 2024; Accepted January 7, 2025; Published June 30, 2025

Intestinal barrier dysfunction increases the risk of perioperative complications.
The immunologic barrier is crucial for maintaining intestinal homeostasis.
Perioperative factors compromise the intestinal immunologic barrier, increasing infection risk.
An imbalance between intestinal microbiota and immune cells affects postoperative recovery.
Clinical intervention studies targeting the intestinal barrier are summarized.

Review Article

Open Access

Impact of intestinal immunologic barrier dysfunction on perioperative complications

Wenxin Shi

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Yajun Hu

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Jin Lan

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Jun Xiong

xiongjun2001@163.com

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Zhiyong Li

zhiyongli@smmu.edu.cn

Department of Pathology, Faculty of Medical Imaging, Naval Medical University, Shanghai 200082, China.

Address correspondence to

Article notes

Received October 28, 2024; Accepted January 7, 2025; Published June 30, 2025

Highlights

Intestinal barrier dysfunction increases the risk of perioperative complications.
The immunologic barrier is crucial for maintaining intestinal homeostasis.
Perioperative factors compromise the intestinal immunologic barrier, increasing infection risk.
An imbalance between intestinal microbiota and immune cells affects postoperative recovery.
Clinical intervention studies targeting the intestinal barrier are summarized.

2025 Jun;3(2):54-70

doi:https://doi.org/10.61189/629158xrbqam

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Accesses: 31

Abstract

Intestinal barrier dysfunction plays a critical role in perioperative complications, especially in the circumstances where immunologic barrier is damaged. This paper reviews the structure of the intestinal immunologic barrier, its interaction with intestinal microbiota, and its effects on intestinal epithelial cells. It emphasizes the key role of the intestinal immunologic barrier in maintaining intestinal homeostasis and explains how its dysfunction increases the risk of infection, anastomotic leakage, gastrointestinal motility disorders, and systemic inflammatory response syndrome during the perioperative period.

Keywords: Intestinal barrier, perioperative complications, immunologic barrier

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ISSN: 2957-5443

Volume 3, Issue 2

June 2025

Pages: 39-70

PDF CITE Accesses: 31

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