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liaochh7@smmu.edu.cnCandidiasis is a substantial cause of perioperative mortality in immunocompromised and immunodeficient patients.
β-glucan and α-mannan are two major pathogen-associated molecular patterns in the Candida albicans cell walls recognized by C-type lectin receptors (CLRs).
CLRs, such as Dectin-1 and Dectin-2, as β-glucan and α-mannan receptors, are essentially involved in recogni tion of Candida albicans.
CLRs are promising drug targets for treating chronic candidiasis.
Open Accessxingzhen@sina.comliaochh7@smmu.edu.cnCandidiasis is a substantial cause of perioperative mortality in immunocompromised and immunodeficient patients.
β-glucan and α-mannan are two major pathogen-associated molecular patterns in the Candida albicans cell walls recognized by C-type lectin receptors (CLRs).
CLRs, such as Dectin-1 and Dectin-2, as β-glucan and α-mannan receptors, are essentially involved in recogni tion of Candida albicans.
CLRs are promising drug targets for treating chronic candidiasis.
Candida albicans (C. albicans) is a ubiquitous commensal in the mammalian flora and the most prevalent fungal pathogen of humans. As an opportunistic fungus, C. albicans can cause mucosal and invasive infections. Invasive candidiasis infected by C. albicans is a leading cause of perioperative death in immunocompromised and immunodeficient patients. The morphological change from the yeast to the mycelium plays a key role in the pathogenesis of C. albicans. C-type lectin receptors (CLRs), including Dectin-1, Dectin-2, Dectin-3, Mincle, and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, are among the pattern recognition receptors expressed by innate immune cells that can recognize C. albicans. The emergence of drug-resistant C. albicans put pressure on the healthcare system, whereby CLRs have also attracted extensive attention from physicians. Thus, in this article, we discuss the interaction between CLRs and C. albicans and the treatment prospects of CLRs on anti-C. albicans.
ISSN: 2957-5443
Volume 1, Issue 1
June 2023
Pages: 1-47
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