Review Article

Open Access

2024 Jun;2(2):76-82

https://doi.org/10.61189/758818obsmms

Advancements in irreversible electroporation ablation technology for treating atrial fibrillation

Binyu Wang

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Tiantian Hu

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Jiuzhou Zhao

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Jincheng Xu

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Banghong Chen

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Yicheng Liu

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Yu Zhou

zhouyu@usst.edu.cn

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Address correspondence to

Article notes

Highlights

Yu Zhou, School of Health Science and Engineering, University of Shanghai for Science and Technology, No.516 Jungong Road, Changbai New Village Street, Yangpu District, Shanghai 200093, China. Tel: 18021042556. E-mail: zhouyu@usst.edu.cn.

Received January 17 2024; Accepted February 7, 2024; Published June 30, 2024

Pulsed field ablation (PFA) demonstrates superior efficacy atrial fibrillation than traditional methods.
Enhanced safety profile of PFA reduces complications in adjacent tissue damage.
Optimized outcomes depends on key PFA parameters such as voltage, pulse width, and frequency.

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Review Article

Open Access

Advancements in irreversible electroporation ablation technology for treating atrial fibrillation

Binyu Wang

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Tiantian Hu

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Jiuzhou Zhao

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Jincheng Xu

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Banghong Chen

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Yicheng Liu

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Yu Zhou

zhouyu@usst.edu.cn

School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Address correspondence to

Article notes

Received January 17 2024; Accepted February 7, 2024; Published June 30, 2024

Highlights

Pulsed field ablation (PFA) demonstrates superior efficacy atrial fibrillation than traditional methods.
Enhanced safety profile of PFA reduces complications in adjacent tissue damage.
Optimized outcomes depends on key PFA parameters such as voltage, pulse width, and frequency.

2024 Jun;2(2):76-82

doi:https://doi.org/10.61189/758818obsmms

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Accesses: 22

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Abstract

Pulsed field ablation (PFA), an emerging treatment method for atrial fibrillation, has demonstrated significant potential in arrhythmia therapy. PFA employs high-intensity, short-duration electric fields to induce irreversible electroporation in myocardial cells, disrupting abnormal cardiac rhythms, and restoring normal heart function. This technique exhibits high success rates and low recurrence rates in animal studies and early clinical trials, offering advantages over traditional methods by reducing damage to adjacent structures such as the esophagus, phrenic nerve, and pulmonary veins. This review examines PFA’s application mechanisms, benefits, key operational parameters and the design and safety of related ablation devices. It emphasizes PFA’s potential to enhance both the efficacy and safety of atrial fibrillation treatment and explores future research directions and technological developments.

Keywords: Irreversible electroporation, pulsed field ablation, atrial fibrillation treatment, ablation devices

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