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Search Result (307)
Perioperative Precision Medicine
Review Article
Open Access
Combining traditional medicine with modern medicine: The role of acupuncture anesthesia in multidisciplinary pain management
Chenlei Qian
Chenlei Qian
2286990788@qq.com
College of Integrated Traditional Chinese and Western Medicine, Nanchang Medical College, Nanchang 330052, Jiangxi, China.
2026 Jun;4(2):205-220
https://doi.org/10.61189/693733xrbrvc
Article Preview PDF CITE

Qian CL. Combining traditional medicine with modern medicine: The role of acupuncture anesthesia in multidisciplinary pain management. Perioper Precis Med. 2026 Jun; 4 (2): 205-220. doi: 10.61189/693733xrbrvc

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Supplementary File Article Preview

Perioperative pain management remains challenging, as inadequate analgesia may delay recovery and increase opioid exposure. Multidisciplinary pain management (MPM) emphasizes multimodal and collaborative strategies, creating opportunities for integrating non-pharmacological interventions. Acupuncture anesthesia (AA), derived from traditional Chinese medicine, has re-emerged as a potential adjunct in perioperative care through modulation of nociceptive transmission, stress responses, and opioid requirements. This review summarizes the historical development, proposed neuroimmune mechanisms, and current clinical applications of AA in modern perioperative settings. Evidence from randomized controlled trials and meta-analyses suggests that AA may reduce postoperative pain scores, opioid consumption, and postoperative nausea and vomiting, and facilitate recovery in selected procedures. Moderate-level evidence supports its adjunctive role in gastrointestinal, orthopedic, and gynecological surgeries, whereas evidence in thoracic, cardiac, and highly invasive procedures remains limited and inconsistent. Critically, current evidence is constrained by small sample sizes, heterogeneous acupuncture protocols, inadequate blinding, regional concentration of studies, and insufficient long-term outcome reporting. These limitations reduce external validity and hinder guideline-level recommendations. Overall, AA shows promise as part of MPM pathways, particularly in enhanced recovery protocols, but standardized intervention protocols and large multicenter high-quality trials are needed before broader implementation in perioperative anesthesia practice.

Perioperative Precision Medicine
Review Article
Open Access
Research progress on pharmacological effects and mechanisms of cycloastragenol
Weiqi Lin
Weiqi Lin
School of Clinical Medicine/Anesthesia Laboratory and Training Center/Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Qin Zhang
Qin Zhang
School of Clinical Medicine/Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Sixu Chen
Sixu Chen
Anesthesia Laboratory and Training Center/School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Xinyi Xie
Xinyi Xie
Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center/School of Pharmacology, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Jiayin Wang
Jiayin Wang
Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center/School of Pharmacology, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Yutong Sun
Yutong Sun
School of Clinical Medicine/Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Qixiang Xu
Qixiang Xu
xuqixiang@wnmc.edu.cn
Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center/School of Pharmacology, Wannan Medical College, Wuhu 241002, Anhui, China.
,
Cuifeng Zhang
Cuifeng Zhang
zhangcuifeng@wnmc.edu.cn
Anesthesia Laboratory and Training Center/Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center/School of Anesthesiology, Wannan Medical College, Wuhu 241002, Anhui, China.
2025 Dec;3(4):207-215
https://doi.org/10.61189/313450skrqzv
Article Preview PDF CITE

Lin WQ, Zhang Q, Chen SX, Xie XY, Wang JY, Sun YT, Xu QX, Zhang CF. Research progress on pharmacological effects and mechanisms of cycloastragenol. Perioper Precis Med. 2025 Dec; 3 (4): 207-215. doi: 10.61189/313450skrqzv

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Article Preview

Cycloastragenol, a key bioactive compound extracted from Astragalus membranaceus, has attracted increasing attention for its therapeutic potential in anti-aging, cancer treatment, and fibrosis prevention. This review summarizes the pharmacological activities of Cycloastragenol at molecular, cellular, and systemic levels, and discusses its efficacy across various disease models and potential perioperative applications. Current evidence demonstrates that Cycloastragenol exerts dose-dependent therapeutic efficacy through specific molecular targets. However, its clinical translation remains limited, particularly in surgical recovery contexts, underscoring the need for further validation through well-designed clinical trials focused on perioperative outcomes.

Perioperative Precision Medicine
Review Article
Open Access
Tailoring perioperative analgesia: Selecting ketamine or dexmedetomidine based on patient-specific factors
Edward Sun
Edward Sun
University of British Columbia, Vancouver, Canada BC V6T 1Z4.
,
Meikun Wang
Meikun Wang
Department of Anesthesia, First Hospital, Jilin University, Changchun 130021, Jilin Province, China.
,
Zongda He
Zongda He
King' s College, London, UK WC2R 2LS.
,
Mingyue Li
Mingyue Li
Department of Anesthesia, Second Hospital, Jilin University, Changchun 130021, Jilin Province, China.
,
Jingping Wang
Jingping Wang
jwang23@MGH.Harvard.edu
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, MA, USA.
2025 Dec;3(4):216-225
https://doi.org/10.61189/577707zkzsmw
Article Preview PDF CITE

Sun E, Wang MK, He ZD, Li MY, Wang JP. Tailoring perioperative analgesia: Selecting ketamine or dexmedetomidine based on patient-specific factors. Perioper Precis Med. 2025 Dec; 3 (4): 216-225. doi: 10.61189/577707zkzsmw

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Article Preview
Ketamine and dexmedetomidine are widely used non-opioid agents for perioperative analgesia and sedation, each with distinct mechanisms and side effect profiles. Dexmedetomidine, an α2-adrenergic agonist, is preferred in patients with hepatic dysfunction due to its stable sedation and lower risk of delirium, though it may cause side effects such as bradycardia and hypotension. Ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, increases heart rate and blood pressure via catecholamine release and provides additional benefits such as anti-inflammatory, neuroprotective, and antidepressant properties. Although both agents have overlapping clinical roles, selection should be guided by patient comorbidities, including cardiac, hepatic, and neurological conditions. This review summarizes current evidence to support individualized decision-making in postoperative pain management.
Perioperative Precision Medicine
Perspective
Open Access
From organ preservation to xenotransplantation: Technological pathways toward sustainable organ replacement
Lu Cheng
Lu Cheng
17687176899@163.com
Department of Cardiovascular Medicine, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences/Affiliated Cardiovascular Hospital of Kunming MedicalUniversity, Kunming 650102, Yunnan, China.2Yunnan Provincial Cardiovascular Clinical Medical Center, Kunming 650000, Yunnan, China.3Yunnan Provincial Cardiovascular Clinical Medical Research Center, Kunming 650000, Yunnan, China.
2026 Jun;4(2):221-224
https://doi.org/10.61189/650911qrvsug
PDF CITE
Cheng L. From organ preservation to xenotransplantation: Technological pathways toward sustainable organ replacement. Perioper Precis Med. 2026 Jun; 4 (2): 221-224. doi: 10.61189/650911qrvsug
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Supplementary File
Perioperative Precision Medicine
Review Article
Open Access
Dual roles of sphingosine-1-phosphate receptor 3 in inflammation, ischemia-reperfusion injury, and vascular homeostasis
Yichen He
Yichen He
School of Anesthesiology, Wannan Medical University, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Xiangyi Zhang
Xiangyi Zhang
School of Anesthesiology, Wannan Medical University, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Qin Zhang
Qin Zhang
School of Clinical Medicine, Wannan Medical University, Wuhu 241002, Anhui, China.; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Weiqi Lin
Weiqi Lin
School of Clinical Medicine, Wannan Medical University, Wuhu 241002, Anhui, China.; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Yan Zhang
Yan Zhang
School of Anesthesiology, Wannan Medical University, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Haiyi Qian
Haiyi Qian
School of Pharmacology, Wannan Medical University, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Wen Ke
Wen Ke
School of Anesthesiology, Wannan Medical University, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
,
Qun Chen
Qun Chen
Pharmacy Department, Wuhu Hospital of Traditional Chinese Medicine, Wuhu 241002, Anhui, China.
,
Xiaolong Yuan
Xiaolong Yuan
Pharmacy Department, The Second Affiliated Hospital of Wannan Medical University, Wuhu 241002, Anhui, China.
,
Cuifeng Zhang
Cuifeng Zhang
zhangcuifeng@wnmc.edu.cn
School of Anesthesiology, Wannan Medical University, Wuhu 241002, Anhui, China; Anesthesia Laboratory and Training Center, Wannan Medical University, Wuhu 241002, Anhui, China; Wuhu Perioperative Monitoring and Prognostic Technology Research and Development Center, Wuhu Basic and Clinical Research and Technology Center for Anesthetic Organ Protection, Wannan Medical University, Wuhu 241002, Anhui, China.
2026 Jun;4(2):225-243
https://doi.org/10.61189/479035poxawz
Article Preview PDF CITE
He YC, Zhang XY, Zhang Q, Lin WQ, Zhang Y, Qian HY, Ke W, Chen Q, Yuan XL, Zhang CF. Dual roles of sphingosine-1-phosphate receptor 3 in inflammation, ischemia-reperfusion injury, and vascular homeostasis. Perioper Precis Med. 2026 Jun; 4 (2): 225-243. doi: 10.61189/479035poxawz
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Article Preview
Sphingosine-1-phosphate receptor 3 (S1PR3) is a member of the G protein-coupled receptor (GPCR) family, structurally characterized by seven transmembrane domains. It exhibits diverse biological functions by binding to three major Gα protein subtypes (Gi/o, Gq, and G12/13), thereby activating downstream signaling pathways such as phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), phospholipase C/calcium (PLC/Ca²⁺), and Ras homolog family member A/Rho-associated coiled-coil containing protein kinase (RhoA/ROCK). S1PR3 displays tissue- and cell-specific expression patterns, with high levels observed in the cardiovascular system (endothelial cells, vascular smooth muscle cells, cardiac fibroblasts), immune system (macrophages, dendritic cells), nervous system (astrocytes, microglia), and liver (hepatocytes, hepatic stellate cells). This expression profile enables S1PR3 to play pivotal roles in regulating inflammation, maintaining vascular homeostasis, repairing liver damage, protecting neural function, and preserving immune balance. Under pathological conditions, S1PR3 exhibits dual functionality. At physiological concentrations or under mild pathological conditions, it exerts protective effects—for instance, preventing cardiomyocyte and hepatocyte apoptosis and maintaining blood-brain barrier (BBB) integrity. Conversely, overactivation leads to tissue damage, including exacerbated inflammatory infiltration (e.g., in acute respiratory distress syndrome, ARDS), promotion of fibrosis (e.g., hepatic fibrosis), and vascular injury (e.g., atherosclerosis). S1PR3 has emerged as a promising therapeutic target for cardiovascular diseases, neurological injuries, and liver disorders. However, clinical application of S1PR3 modulators is hindered by off-target effects (e.g., bradycardia due to insufficient subtype selectivity) and risks of immunosuppression, underscoring the need for more selective ligands and personalized therapeutic regimens.
Perioperative Precision Medicine
Review Article
Open Access
Bacterial infection and sepsis-associated inflammation: Mechanistic insights and emerging clinical perspectives
Xuesong Liu
Xuesong Liu
School of Basic Medical Sciences, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
,
Jiejin Yang
Jiejin Yang
College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
,
Zhihao Hu
Zhihao Hu
School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
,
Huiting Wei
Huiting Wei
School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
,
Rong Zhang
Rong Zhang
College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
,
Zhuoqun Huang
Zhuoqun Huang
School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
,
Jiao Song
Jiao Song
songjiaoedu@163.com
School of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China.
2026 Jun;4(2):244-277
https://doi.org/10.61189/734294ljkawj
Article Preview PDF CITE
Liu XS, Yang JJ, Hu ZH, Wei HT, Zhang R, Huang ZQ, Song J. Bacterial infection and sepsis-associated inflammation: Mechanistic insights and emerging clinical perspectives. Perioper Precis Med. 2026 Jun; 4 (2): 244-277. doi: 10.61189/734294ljkawj
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Sepsis is typically initiated by bacterial infection and the associated immune dysregulation displays a complex, dynamic biphasic immune response characterized by hyperinflammation followed by immunosuppression. In the initial period, pathogens activate the innate immune system through receptors such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs), resulting in the massive release of cytokines, including IL-1β, IL-6, and IFN-γ, thereby initiating a "cytokine storm" that leads to vascular endothelial damage, complement activation, and the induction of abnormal cellular aggregation. Sustained activation of inflammatory signals initiates inflammasome-mediated cell death, including pyroptosis-apoptosis-necroptosis (PANoptosis), leading to systemic inflammation and organ dysfunction. Later, the host develops an immunosuppressive phase characterized by increased anti-inflammatory mediators (e.g., IL-10 and TGF-β), exhaustion of B, T, and NK cells, and immune checkpoint-mediated immune paralysis. The stepwise progression of these two stages suggests that sepsis is not simply a consequence of uncontrolled inflammation but rather reflects immune system reprogramming. A better understanding of the molecular basis of inflammation and immunosuppression, particularly the crosstalk among cell death pathways, metabolic reprogramming, and immune regulation, may facilitate timely precision interventions and the restoration of host immune homeostasis in sepsis.
Medical Artificial Intelligence
Research Article
Open Access
Optimizing patient flow with an iBeacon-based in-hospital navigation system: A framework and case study
Zhigang Sun
Zhigang Sun
Department of Information Management, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Pudong New Area, Shanghai 201318, China.
,
Feifei Gu
Feifei Gu
Department of Information Management, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Pudong New Area, Shanghai 201318, China.
,
Bei Tian
Bei Tian
Department of Information Management, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Pudong New Area, Shanghai 201318, China.
,
Ming Hu
Ming Hu
398429579@qq.com
Department of Information Management, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Pudong New Area, Shanghai 201318, China.
2026 Jun;2(1):1-6
https://doi.org/10.61189/787580orkjwc
Article Preview PDF CITE
Sun ZG, Gu FF, Tian B, Hu M. Optimizing patient flow with an iBeacon-based in-hospital navigation system: A framework and case study. Med Artif Intell. 2026 Jun; 2 (1): 1-6. doi: 10.61189/787580orkjwc
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Background: Hospital outpatient services handle a large number of patients daily, with busy and standardized processes, making them crucial to the hospital' s daily operations. Approximately one-third of outpatients seek assistance at the information desk daily, with 60% of these inquiries related to department location and the treatment process. Despite the hospital displaying prominent maps and signs, many patients still get lost, repeatedly search for departments, or endure long waits, hindering patient satisfaction. Objective: To design and implement an intelligent indoor navigation system deeply integrated with the hospital information system (HIS). This system helps patients quickly and conveniently plan their routes, improve the overall medical experience, reduce the workload of medical staff and hospital operating costs, and implement the hospital' s "one-phone-for-all" outpatient service process optimization concept. Methods: This study constructed a real-time navigation system integrating Bluetooth iBeacon positioning technology, a 3D electronic map, and a WeChat official account platform. The system architecture is deeply integrated with the HIS to achieve proactive navigation based on the treatment process. This study employed a retrospective cohort analysis to compare the differences in patient time spent on key medical routes before and after the system' s implementation, and analyzed its application effectiveness using actual system usage data. Results: The system provides real-time, intelligent, and dynamic route guidance and path planning, effectively reducing patient navigation time, optimizing the medical experience, and lowering the workload and operating costs of patient guidance services. During the COVID-19 pandemic, the system provided strong support for the implementation of hospital epidemic prevention measures, reduced unnecessary contact between medical staff and patients, and ensured the safety of both.

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